Nice to see you here on TWP, Big Dad!

I hope I can answer your question. I use two MRC Control Master 20's, and a Tech 4 using one common rail, and what I have are two mainlines with a yard in between the two. I have it controlled so I can run a switcher back and forth while trains run on the main.
So to answer your question, in a word, "yes". You just need to use some DPDT switches to make it go. We have a modeler here on the site named HOScalemodeler 1967 who is a guru with DC wiring who could answer just about anything.
Please show us your layout as you go along, and don't be shy in asking away! There are no dumb questions here! Everyone has to start somewhere!

Hope you enjoy your stay at TWP!